Aminosteril N-Hepa 8%

​Amino acid solution for parenteral nutrition of patients with hepatic insufficiency

  • Complete and balanced amino acid profile for effective hepatic encephalopathy treatment
  • High concentration of branched chain AA and reduced concentration of aromatic AA
  • Low methionine concentration
  • High arginine concentration
  • Effective in maintaining a nitrogen balance
  • Normalization of pathological plasma amino acid levels
  • Reduced likelihood of metabolically produced toxic amines

  • Supply of amino acids as part of a parenteral nutrition in  severe forms of hepatic insufficiency with and without  hepatic encephalopathy when oral or enteral nutrition is  impossible or insufficient or contraindicated

  • Aminosteril 8% N-Hepa ,500 ml glass bottle,1.0 – 1.25 ml/kg body wt/hr (=0.08 – 0.1 g amino acids/kg body wt/hr)

  • Normalization of the pathological plasma amino acid levels in patients with hepatic  insufficiency
  • High arginine content to enhance urea production and improve systemic ammonia clearance
  • Helps reducing hyperammonaemia effect and further exposure to hepatic encephalopathy
  • Improves nitrogen balance

  1. Holm E., Striebel JP., Möller P., Hartmann M. Amino aid solution for parenteral nutrition ad for adjunct treatment of encephalopathy in liver cirrhosis. Studies concerning 120 patients. In Metabolism and clinical implications of branched chain amino and ketoacids (Eds Walser M and Williamson JR, Elsevier North Holland, NY, Amsterdam 1981, pp510-518.
  2. Holm E, Striebel JP, Meisinger E, Haux P, Langhans W, Becker HD. Aminosäurengemiche zur parenteralen Ernährung bei Leber-insuffzienz. Infusionstherapie 1978; 5:274-292.
  3. Kato M., Miwa Y., Tajika M., Hiraoka T., Muto Y., Moriwaki H. Preferential use of branch-chain amino acids as an energy substrate in patients with cirrhosis. Intern Med 1998; 37:429-434.
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  6. Freund H., Fischer J. Our experience with F080 in the treatment of hepatic coma in 63 patients. In  Amino acid and ammonia metabolism in hepatic failure. (Ed Holm E). Witzstrock, Baden-Baden-Köln NY, 1982, pp172-183.
  7. Rakette S., Reimann H-J., Fischer M., Bottermann P. Therapeutic influence on hepatic encephalopathy in patients with cirrhosis of the liver using a special amino acid solution: Biochemical and clinical findings. In Hrsg. Aminosären-und Ammoniakstoff-wechsel bei Leberinsuffizienz. (Ed Holm E). Witzstrock, Baden- Baden-Köln NY, 1982, pp203-210.
  8. Cerra FB., Cheung NK, Fischer JE., et al. A multicenter trial of branched chain enriched amino acid infusion (F080) in hepatic encephalopathy . Hetatology 1982;2:699.
  9. Fischer JE. Branched-chain-enriched amino acid solutions in patients with liver failure: an early  example of nutritional pharmacology. JPEN 1990; 14(5):249S-256S.
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  14. Wahren J., Denis J., Desurmont P., et al. Is intravenous administration of branched chain amino acids effective in the treatment of hepatic encephalopathy? A multicenter study. Hepatology 1983;3(4):475-480.
  15. Cerra FB., Cheung NK., Fischer JE., Kaplowitth N., Schiff ER., Dienstag JL., Bower RH., Mabry CD., Leevy CM., Kiernan T. Disease-specific amino acid infusion (F080) in hepatic encephalopathy : a prospective , randomised, double-blind, controlled trial. JPEN 1985;9:288-295.
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Characteristics

Aminsterile N Hepa

AA gms

40 gm

BCAA

42 %

AAA

2 %

Arginine

13.4 %

Total Nitrogen (g/l/pack)

12.9

Total Kcals/l

320

Osmolarity (mosmol/L)

770

Infusion Rate

1.25 ml/kg body wt/hr

Max.Dosage (ml/kg bw/day)

18.75

Shelf life (months)

36

Route of Adm

Peripheral