Levobupivakaín, S(-) – enantiomér racemickej zmesi bupivakaínu, je dlhodobo pôsobiace
anestetikum s nižším rizikom kardiotoxicity a neurotoxicity v porovnaní s bupivakaínom.1 – 5
Preukázaná kompatibilita (chemická a fyzikálna stabilita) Levobupivacaine Kabi 5 mg/ml zriedeného roztokom chloridu sodného s klonidínom, morfínom, fentanylom a sufentanylom.1
1. SPC Levobupivacaine Kabi; 2. Compagna et al. Comparative study between Levobupivacaine and Bupivacaine for hernia surgery in
the elderly; BMC Surgery 2012, 12(Suppl 1):S12; http://www.biomedcentral.com/1471 2482/12/S1/S12; 3. Gristwood at al. Cardiac and CNS
toxicity of levobupivacaine: strengths of evidence for advantage over bupivacaine; Drug Saf. 2002;25(3):153-63. DOI: 10.2165/00002018-
200225030-00002; 4. Gristwood at al. Levobupivacaine: a new safer long acting local anaesthetic agent; DOI: 10.1517/13543784.8.6.861;
5. McClellan et al. Levobupivacaine; Drugs. 1998 Sep;56(3):355-62; discussion 363-4.; DOI: 10.2165/00003495-199856030-00005.
anestetikum s nižším rizikom kardiotoxicity a neurotoxicity v porovnaní s bupivakaínom.1 – 5
Preukázaná kompatibilita (chemická a fyzikálna stabilita) Levobupivacaine Kabi 5 mg/ml zriedeného roztokom chloridu sodného s klonidínom, morfínom, fentanylom a sufentanylom.1
1. SPC Levobupivacaine Kabi; 2. Compagna et al. Comparative study between Levobupivacaine and Bupivacaine for hernia surgery in
the elderly; BMC Surgery 2012, 12(Suppl 1):S12; http://www.biomedcentral.com/1471 2482/12/S1/S12; 3. Gristwood at al. Cardiac and CNS
toxicity of levobupivacaine: strengths of evidence for advantage over bupivacaine; Drug Saf. 2002;25(3):153-63. DOI: 10.2165/00002018-
200225030-00002; 4. Gristwood at al. Levobupivacaine: a new safer long acting local anaesthetic agent; DOI: 10.1517/13543784.8.6.861;
5. McClellan et al. Levobupivacaine; Drugs. 1998 Sep;56(3):355-62; discussion 363-4.; DOI: 10.2165/00003495-199856030-00005.